Anesthesia for Geriatric Patients - Pharmacologic Changes Associated with Aging
Pharmacokinetic Changes in Elderly
Pharmacokinetic Changes in Elderly
Pharmacokinetic Changes in Elderly
Pharmacokinetic Changes in Elderly
- Protein binding of anesthetic drugs is reduced because of decreased levels of circulating serum protein—for example, albumin. Therefore, their pharmacologic effects are potentiated.
- Reduction in blood volume, an increase in percentage of body fat, and decreases in hepatic and renal function result in prolonged elimination for drugs dependent on redistribution and/or elimination for termination of action thereby prolonging anesthetic effects.
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