Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. Explore these free sample topics:
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Placental transport of anesthetics occurs primarily by passive diffusion. Drugs with higher diffusion constants more readily cross placental membranes. Factors that promote rapid diffusion include the following:
Most of the inhalational and IV anesthetics readily cross the placenta because they have a low molecular weight, have high lipid solubility, are relatively nonionized, and are minimally protein bound.