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Placental transport of anesthetics occurs primarily by passive diffusion. Drugs with higher diffusion constants more readily cross placental membranes. Factors that promote rapid diffusion include the following:
Most of the inhalational and IV anesthetics readily cross the placenta because they have a low molecular weight, have high lipid solubility, are relatively nonionized, and are minimally protein bound.
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Placental transport of anesthetics occurs primarily by passive diffusion. Drugs with higher diffusion constants more readily cross placental membranes. Factors that promote rapid diffusion include the following:
Most of the inhalational and IV anesthetics readily cross the placenta because they have a low molecular weight, have high lipid solubility, are relatively nonionized, and are minimally protein bound.
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