Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.
L-tryptophan is an essential amino acid that is converted by the body to 5–hydroxytryptophan (5–HTP) and then to serotonin. Both L-tryptophan and 5–HTP cross the blood-brain barrier and have sedative effects. Depletion of endogenous tryptophan can cause a relapse in depression symptoms.
Metabolism and Excretion: Unknown
Use Cautiously in:
CNS: ataxia, headache, drowsiness, lightheadedness
EENT: visual blurring
GI: heartburn, abdominal pain, dry mouth, nausea
Hemat: eosinophilia-myalgia syndrome
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Natural Drug Interaction
PO: (Adults) Insomnia– 1 gram 20 minutes before bedtime; Depression– 300 mg/day; Prementrual syndrome– 6 grams/day; Smoking cessation– 50 mg/kg/day.
Tablets: 500 mg
Improvement in insomnia and premenstrual disorder.
Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. Learn more.