Treatment of relapsing forms of multiple sclerosis.
Antiviral and immunoregulatory properties produced by interacting with specific receptor sites on cell surfaces may explain beneficial effects. Produced by recombinant DNA technology. Pegylation prolongs duration of action.
Reduced incidence of relapse (neurologic dysfunction) and slowed physical disability.
Administer prophylactic analgesics and/or antipyretics to prevent or minimize flu-like symptoms.
SC: Inject subcut in abdomen, back of upper arm, and thigh every 14 days; rotate sites. Prefilled pens are for single dose; discard after use.
Instruct patient in correct technique for injection and care and disposal of equipment. Avoid injecting into areas of skin irritation, redness, bruising, infection, or scarring. Check injection site 2 hr after injection for redness, swelling, and tenderness. Notify health care professional if skin reaction does not clear in a few days. Caution patient not to reuse needles or syringes and provide patient with a puncture-resistant container for disposal.
Instruct patient to take medication as directed; do not change dose or schedule without consulting health care professional. Advise patient to read Medication Guide prior to starting therapy and with each Rx refill in case of changes.
Inform patient that flu-like symptoms (headache, fever, chills, myalgia, sweating, malaise, tiredness) may occur during therapy. Acetaminophen may be used for relief of fever and myalgias. Flu-like symptoms are not contagious.
Advise patient to notify health care professional immediately if signs and symptoms of liver disease (yellowing of skin or whites of eyes, nausea, loss of appetite, tiredness, bleeding easily, confusion, sleepiness, dark colored urine, pale stools), depression, suicidal thoughts, seizures, allergic reactions (itching; swelling of face, eyes, lips, tongue, throat; trouble breathing; feeling faint; anxiousness; rash; hives) or autoimmune diseases (easy bleeding or bruising, thyroid gland problems, autoimmune hepatitis) occur.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Rep: Advise patient to notify health care professional if pregnancy is planned or suspected or if breast feeding. Encourage patients to enroll in Pregnancy Registery by calling 1-866-810-1462 or visiting https://www.plegridypregnancyregistry.com/.
Decrease in the frequency of relapse (neurologic dysfunction) in patients with relapsing-remitting multiple sclerosis.
peginterferon beta-1a is a sample topic from the Davis's Drug Guide.
Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. Learn more.