vascular endothelial growth factor antagonists
Binds to and inactivates Vascular Endothelial Growth Factor (VEGF) receptors which normally promote neovascularization and vascular permeability.
Absorption: Action is local following intravitreal injection, minimal systemic absorption occurs.
Distribution: Distribution occurs mainly in the vitreal space.
Metabolism and Excretion: Used up in the binding process and degraded by proteolytic enzymes.
Half-life: 5–6 days (plasma).
TIME/ACTION PROFILE (improved visual acuity)
|intravitreal||rapid (within 4 wk)||8–12 wk||maintained throughout treatment|
Ocular/periocular infectionActive intraocular inflammation
Use Cautiously in:
CV: MI, STROKE
EENT: conjunctival hemorrhage, eye pain, blurred vision, cataract, corneal edema, corneal erosion, conjunctival hyperemia, detachment of retinal pigment epithelium, endophthalmitis (from procedure), eyelid edema, foreign body sensation, injection site hemorrhage/pain, intraocular inflammation, ↑ intraocular pressure, ↑ lacrimation, retinal detachment (from procedure), vitreous detachment, vitreous floaters
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Neovascular (Wet) AMD
Intravitreal (Adults): 2 mg every 4 wk for first 12 wk, then 2 mg every 8 wk (some patients may continue to require every 4 wk dosing). After one year of therapy, may consider dosing every 12 wk.
Macular Edema Following CRVO
Intravitreal (Adults): 2 mg every 4 wk.
Diabetic Macular Edema and Diabetic Retinopathy
Intravitreal (Adults): 2 mg every 4 wk for first 5 injections, then 2 mg every 8 wk (some patients may continue to require every 4 wk dosing).
Solution for injection: 2 mg/0.05 mL
Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drugs, procedures, and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and PRIME Journals. Complete Product Information.