PrabotulinumtoxinA is not interchangeable with other botulinum toxin products.
IM (Adults): 20 units, divided in five equal aliquots of 4 units; may be repeated every 3 mo.
Lyophilized powder for injection: 100 units/vial
Monitor for asthenia, generalized muscle weakness, diplopia, blurred vision, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence, and breathing difficulties. Medication may spread from injection site to distant parts of the body.
Assess for signs of hypersensitivity reaction (dyspnea, rash, pruritus, laryngeal edema, wheezing), dysphagia, and breathing difficulties following administration. Keep epinephrine, an antihistamine, and resuscitation equipment close by in the event of an anaphylactic reaction.
Botulinum toxin products are not interchangeable. Determine appropriate product prior to administration.
Injections should be made no more frequently than every 3 mo and using the lowest effective dose.
To reduce complication of eyelid ptosis: avoid injection near the levator palpebrae superioris, particularly in patients with larger brow depressor complexes; place lateral corrugator injections at least 1 cm above the bony supraorbital ridge; ensure injected volume/dose is accurate and kept to a minimum; and avoid injecting toxin closer than 1 centimeter above the central eyebrow.
IM Reconstitute each vial slowly with 2.5 mL of 0.9% NaCl for a concentration of 4 units/0.1 mL. Discard the vial if a vacuum does not pull the diluent into the vial. Rotate vial to mix. Solution is clear and colorless; do not administer solution that are cloudy, discolored, or contain particulate matter. Solution is stable for up to 24 hr if refrigerated and protected from light. Do not freeze. Use vial for only 1 injection session. Discard unused solution. Draw at least 0.5 mL of reconstituted toxin into syringe and expel any air bubbles in syringe barrel. Remove needle and attach a 30-33 gauge needle. Confirm patency of needle. Inject 0.1 mL (4 Units) IM into each of five sites: inferomedial and superior middle of each corrugator, and one in mid-line of procerus muscle, for total dose of 20 Units.
Explain purpose and effects of Jeuveau to patient.
Advise patient to inform health care professional if any unusual symptoms (including difficulty with swallowing, speaking or breathing) occur, or if any known symptom persists or worsens.
May cause loss of strength, muscle weakness, blurred vision, or drooping eyelids. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
Inform patients Jeuveau may cause eye dryness. Advise patient to notify health care professional if symptoms of eye dryness (eye pain, eye irritation, photosensitivity, changes in vision) occur.
Inform patient that injection may to spread from injection site to distant parts of the body. May occur within hrs or several wks after injection. Advise patient to notify health care professional immediately if swallowing, speech, or respiratory disorders arise.
Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Decreased appearance of glabellar (frown) lines.
prabotulinumtoxina is a sample topic from the Davis's Drug Guide.
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