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West Nile virus (WNV)
Although it first appeared in the U.S. in 1999, within 5 years WNV had established itself as endemic in the US.
Responsible agent is a single-strand RNA virus of the family Flavivirus.
Its enzootic cycle involves several species of mosquitoes and birds before infecting humans; however, it is transmitted to humans from the bite of Culex species of mosquitoes.
Incubation period of 2–14 days.