Acute Hemolytic Anemia
First Things First (assess & treat for the following)
First Things First (assess & treat for the following)
First Things First (assess & treat for the following)
- Characterized by premature RBC destruction greater than increased RBC production (erythrocytosis), spherocytosis without bleeding
- Most cases are caused by extrinsic factors: drugs, exogenous antibodies, mechanical trauma, infections & toxins.
- 50% of cases are idiopathic or primary and not associated with pre-existing disease.
- Autoimmune hemolytic anemia has shortened RBC lifespan with positive Coombs’ test.
- ≥80% of cases are of warm reactive autoantibodies of IgG subclass; the rest are cold reactive.
- Hemolysis occurs when nonphagocytized RBCs take on a spherical shape, rendering them poorly deformable and rigid.
- These acquired spherocytes make them apt to destruction.
- Indirect hyperbilirubinemia is usually present and highly suggestive of hemolytic anemia.
- Watch for signs of organ dysfunction.
- Obtain early hematologic consult.
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