Clinical Anesthesia Procedures
Neuromuscular Blockade - Reversal of Neuromuscular Blockade
Recovery from SCh-induced depolarizing blockade
Recovery from SCh-induced depolarizing blockade usually occurs within 5 to 10 minutes following a 1 mg/kg IV dose. Patients with atypical or inhibited plasma cholinesterase could have a greatly prolonged duration of blockade. Reversal of phase II blockade occurs spontaneously within 10 to 15 minutes in approximately 50% of patients. It is advisable to allow patients with prolonged blockade to recover spontaneously for 20 to 25 minutes and then reversal with an anticholinesterase agent may be attempted if there is no further improvement in twitch strength. Earlier reversal could potentiate the block.
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Citation
Pino, Richard M., editor. "Neuromuscular Blockade - Reversal of Neuromuscular Blockade." Clinical Anesthesia Procedures, 9th ed., Wolters Kluwer, 2019. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728200/all/Neuromuscular_Blockade___Reversal_of_Neuromuscular_Blockade.
Neuromuscular Blockade - Reversal of Neuromuscular Blockade. In: Pino RMR, ed. Clinical Anesthesia Procedures. Wolters Kluwer; 2019. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728200/all/Neuromuscular_Blockade___Reversal_of_Neuromuscular_Blockade. Accessed September 27, 2023.
Neuromuscular Blockade - Reversal of Neuromuscular Blockade. (2019). In Pino, R. M. (Ed.), Clinical Anesthesia Procedures (9th ed.). Wolters Kluwer. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728200/all/Neuromuscular_Blockade___Reversal_of_Neuromuscular_Blockade
Neuromuscular Blockade - Reversal of Neuromuscular Blockade [Internet]. In: Pino RMR, editors. Clinical Anesthesia Procedures. Wolters Kluwer; 2019. [cited 2023 September 27]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728200/all/Neuromuscular_Blockade___Reversal_of_Neuromuscular_Blockade.
* Article titles in AMA citation format should be in sentence-case
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T1 - Neuromuscular Blockade - Reversal of Neuromuscular Blockade
ID - 728200
ED - Pino,Richard M,
BT - Clinical Anesthesia Procedures
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PB - Wolters Kluwer
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DB - Anesthesia Central
DP - Unbound Medicine
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