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Anesthesia for Geriatric Patients - Pharmacologic Changes Associated with Aging

Anesthesia for Geriatric Patients - Pharmacologic Changes Associated with Aging is a topic covered in the Clinical Anesthesia Procedures.

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Pharmacokinetic Changes in Elderly

Pharmacokinetic Changes in Elderly

  1. Protein binding of anesthetic drugs is reduced because of decreased levels of circulating serum protein—for example, albumin. Therefore, their pharmacologic effects are potentiated.
  2. Reduction in blood volume, an increase in percentage of body fat, and decreases in hepatic and renal function result in prolonged elimination for drugs dependent on redistribution and/or elimination for termination of action thereby prolonging anesthetic effects.

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Citation

Pino, Richard M., editor. "Anesthesia for Geriatric Patients - Pharmacologic Changes Associated With Aging." Clinical Anesthesia Procedures, 9th ed., Wolters Kluwer, 2019. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728319/all/Anesthesia_for_Geriatric_Patients___Pharmacologic_Changes_Associated_with_Aging.
Anesthesia for Geriatric Patients - Pharmacologic Changes Associated with Aging. In: Pino RM, ed. Clinical Anesthesia Procedures. 9th ed. Wolters Kluwer; 2019. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728319/all/Anesthesia_for_Geriatric_Patients___Pharmacologic_Changes_Associated_with_Aging. Accessed April 22, 2019.
Anesthesia for Geriatric Patients - Pharmacologic Changes Associated with Aging. (2019). In Pino, R. M. (Ed.), Clinical Anesthesia Procedures. Available from https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728319/all/Anesthesia_for_Geriatric_Patients___Pharmacologic_Changes_Associated_with_Aging
Anesthesia for Geriatric Patients - Pharmacologic Changes Associated With Aging [Internet]. In: Pino RM, editors. Clinical Anesthesia Procedures. Wolters Kluwer; 2019. [cited 2019 April 22]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728319/all/Anesthesia_for_Geriatric_Patients___Pharmacologic_Changes_Associated_with_Aging.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Anesthesia for Geriatric Patients - Pharmacologic Changes Associated with Aging ID - 728319 ED - Pino,Richard M, BT - Clinical Anesthesia Procedures UR - https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728319/all/Anesthesia_for_Geriatric_Patients___Pharmacologic_Changes_Associated_with_Aging PB - Wolters Kluwer ET - 9 DB - Anesthesia Central DP - Unbound Medicine ER -