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Anesthesia for Obstetrics and Gynecology - Placental Transfer of Drugs

Anesthesia for Obstetrics and Gynecology - Placental Transfer of Drugs is a topic covered in the Clinical Anesthesia Procedures.

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Anesthesia Central

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Placental transport of anesthetics

Placental transport of anesthetics occurs primarily by passive diffusion. Drugs with higher diffusion constants more readily cross placental membranes. Factors that promote rapid diffusion include the following:

  1. Low molecular weight (<600 Da)
  2. High lipid solubility
  3. Low degree of ionization
  4. Low protein binding

Most of the inhalational and IV anesthetics readily cross the placenta because they have a low molecular weight, have high lipid solubility, are relatively nonionized, and are minimally protein bound.

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Citation

Pino, Richard M., editor. "Anesthesia for Obstetrics and Gynecology - Placental Transfer of Drugs." Clinical Anesthesia Procedures, 9th ed., Wolters Kluwer, 2019. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728344/all/Anesthesia_for_Obstetrics_and_Gynecology___Placental_Transfer_of_Drugs.
Anesthesia for Obstetrics and Gynecology - Placental Transfer of Drugs. In: Pino RM, ed. Clinical Anesthesia Procedures. 9th ed. Wolters Kluwer; 2019. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728344/all/Anesthesia_for_Obstetrics_and_Gynecology___Placental_Transfer_of_Drugs. Accessed April 20, 2019.
Anesthesia for Obstetrics and Gynecology - Placental Transfer of Drugs. (2019). In Pino, R. M. (Ed.), Clinical Anesthesia Procedures. Available from https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728344/all/Anesthesia_for_Obstetrics_and_Gynecology___Placental_Transfer_of_Drugs
Anesthesia for Obstetrics and Gynecology - Placental Transfer of Drugs [Internet]. In: Pino RM, editors. Clinical Anesthesia Procedures. Wolters Kluwer; 2019. [cited 2019 April 20]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728344/all/Anesthesia_for_Obstetrics_and_Gynecology___Placental_Transfer_of_Drugs.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Anesthesia for Obstetrics and Gynecology - Placental Transfer of Drugs ID - 728344 ED - Pino,Richard M, BT - Clinical Anesthesia Procedures UR - https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728344/all/Anesthesia_for_Obstetrics_and_Gynecology___Placental_Transfer_of_Drugs PB - Wolters Kluwer ET - 9 DB - Anesthesia Central DP - Unbound Medicine ER -