Anesthesia for Obstetrics and Gynecology - Placental Transfer of Drugs
Placental transport of anesthetics
Placental transport of anesthetics occurs primarily by passive diffusion. Drugs with higher diffusion constants more readily cross placental membranes. Factors that promote rapid diffusion include the following:
- Low molecular weight (<600 Da)
- High lipid solubility
- Low degree of ionization
- Low protein binding
Most of the inhalational and IV anesthetics readily cross the placenta because they have a low molecular weight, have high lipid solubility, are relatively nonionized, and are minimally protein bound.
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Citation
Pino, Richard M., editor. "Anesthesia for Obstetrics and Gynecology - Placental Transfer of Drugs." Clinical Anesthesia Procedures, 9th ed., Wolters Kluwer, 2019. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728344/all/Anesthesia_for_Obstetrics_and_Gynecology___Placental_Transfer_of_Drugs.
Anesthesia for Obstetrics and Gynecology - Placental Transfer of Drugs. In: Pino RMR, ed. Clinical Anesthesia Procedures. Wolters Kluwer; 2019. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728344/all/Anesthesia_for_Obstetrics_and_Gynecology___Placental_Transfer_of_Drugs. Accessed December 5, 2024.
Anesthesia for Obstetrics and Gynecology - Placental Transfer of Drugs. (2019). In Pino, R. M. (Ed.), Clinical Anesthesia Procedures (9th ed.). Wolters Kluwer. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728344/all/Anesthesia_for_Obstetrics_and_Gynecology___Placental_Transfer_of_Drugs
Anesthesia for Obstetrics and Gynecology - Placental Transfer of Drugs [Internet]. In: Pino RMR, editors. Clinical Anesthesia Procedures. Wolters Kluwer; 2019. [cited 2024 December 05]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728344/all/Anesthesia_for_Obstetrics_and_Gynecology___Placental_Transfer_of_Drugs.
* Article titles in AMA citation format should be in sentence-case
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