glycopyrrolate oral solution
Prevention of excessive drooling associated with neurologic conditions in patients 3–16 yr.
Competitively inhibits peripheral cholinergic receptors, including salivary glands.
↓ problem drooling.
Absorption: Absorption following oral administration is low and variable; absorption is ↓ by a high fat meal.
Metabolism and Excretion: Excreted mostly unchanged in urine (65–80%), small amount eliminated as metabolites.
Half-life: 3–3.2 hr.
|PO||unknown||2.6–3.1 hr||6–8 hr|
- Conditions or concurrent drug therapy for which anticholinergic therapy is contraindicated including glaucoma, paralytic ileus, unstable cardiovascular status due to acute hemorrhage, severe ulcerative colitis, toxic megacolon as a complication of ulcerative colitis, myasthenia gravis
- Concurrent use of potassium chloride capsules or tablets (passage through GI tract may be delayed).
Use Cautiously in:
- High ambient temperatures; ↑ risk of heat prostration (fever and heat stroke) due to ↓ sweating)
- Renal impairment
- Autonomic neuropathy
- Ulcerative colitis (↑ doses may ↑ risk of paralytic ileus ["toxic megacolon"] )
- Coronary heart disease, HF, cardiac tachyarrhythmias, tachycardia, or hypertension
- Hiatal hernia (may aggravate reflux esophagitis)
- OB: Use in pregnant women only if clearly needed
- Lactation:Use cautiously during lactation
- Pedi: Safety and effectiveness not established in children <3 yr.
Adverse Reactions/Side Effects
CNS: SEIZURES, headache, abnormal behavior, agression, agitation, crying, drowsiness, irritability, moaning, mood altertion, poor impulse control, restlessness
EENT: nasal congestion, blurred vision, nasal dryness, nystagmus
Resp: ↑ viscosity of secretions
GI: INCOMPLETE MECHANICAL INTESTINAL OBSTRUCTION , constipation , dry mouth, vomiting, abdominal discomfort, abdominal distention, abnormal taste, chapped lips, diarrhea, flatulence, intestinal pseudo-obstruction
GU: urinary retention
Derm: flushing, dry skin, pallor, pruritus, rash
F and E: dehydration
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
PO: (Children 3–16 yr): 0.02 mg/kg three times daily initially; titrate in increments of 0.02 mg/kg every 5–7 days (not to exceed 0.1 mg/kg three times daily or 1.5–3 mg per dose ).
Oral solution (cherry): 1 mg/5 mL
- Assess for constipation (abdominal distension, pain, nausea, vomiting), especially within 4–5 days of initial dose or after dose ↑.
- PO: Administer at least 1 hr before or 2 hrs after meals.
- Instruct patient or parent to take glycopyrrolate as directed. Use an accurate measuring device (dosing cup) for correct dosing and administer with an oral syringe to ensure dose is taken. Dosing is started low and titrated slowly over several wk; do not ↑ dose without consulting health care professional. Advise patient/parent to read Patient and Caregiver Information prior to starting therapy and with each Rx refill.
- May cause drowsiness or blurred vision. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
- If constipation, diarrhea, signs of urinary retention (inability to urinate, dry diapers or undergarments, irritability, crying), or signs of hypersensitivity (rash, hives, allergic reaction) occur, stop administering glycopyrrolate and notify health care professional.
- May cause ↓ sweating; avoid overheating. Avoid exposure to hot or very warm environments and notify health care professional immediately if signs of heatstroke (hot, red skin; ↓ alertness or unconsciousness, fast, weak pulse; fast, shallow breathing; ↑ temperature.
- Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
↓ in chronic, severe drooling.
Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. Learn more.