Trade Name(s)

  • Pizensy

Ther. Class.


Pharm. Class.



Chronic idiopathic constipation.


Acts as an osmotic agent, drawing water into the lumen of the GI tract.

Therapeutic Effect(s):

Increased complete, spontaneous bowel movements.


Absorption: Minimally absorbed following oral administration.

Distribution: Unknown.

Metabolism and Excretion: Excreted in fecal contents.

Half-life: 2.4 hr.

TIME/ACTION PROFILE (bowel movement)



Contraindicated in:

  • GI obstruction;
  • Galactosemia.

Use Cautiously in:

  • OB:   Safety not established in pregnancy;
  •  Lactation:  Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
  • Pedi:   Safety and effectiveness not established in children.

Adverse Reactions/Side Effects

CV: hypertension

GI: abdominal distention, abdominal pain, diarrhea, flatulence

GU: urinary tract infection

MS: ↑ creatine kinase

Resp: upper respiratory tract infection

* CAPITALS indicate life-threatening.
Underline indicate most frequent.



May ↓ absorption and effectiveness of concurrently administered medications; administer other medications ≥2 hr before or after lactitol.


PO (Adults): 20 g once daily; ↓ to 10 g once daily if persistent, loose stools.


Powder: 280 g/bottle, 560 g/bottle


  • Assess bowel sounds and frequency, quantity, and consistency of stools periodically during therapy.

Potential Diagnoses


  • PO Administer once daily with meals.
    • Multi-dose bottle: Use bottle cap to measure 10 g of powder. Fill twice for 20-g dose. Pour dose into empty 8 oz glass. Add 4 oz of water, juice or other beverage (coffee, tea, soda) and stir to dissolve. Drink entire contents of glass.
    • Administer oral medications at least 2 hr before or 2 hr after lactitol.

Patient/Family Teaching

  • Instruct patient to take lactitol as directed and to take other medications at least 2 hr before or 2 hr after lactitol.
  • Advise patient to stop lactitol and notify health care professional if persistent loose stools occur.
  • Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

Increased complete, spontaneous bowel movements.

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Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drugs, procedures, and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and PRIME Journals. .