abametapir
General
**Off Market Drug**
This medication is no longer available in the United States. Information provided here is for reference purposes only.
Pronunciation:
a-ba-meta-pir
Trade Name(s)
- Xeglyze
Ther. Class.
pediculocides
Pharm. Class.
metalloproteinase inhibitors
Indications
Head lice.
Action
Inhibits metalloproteinase which prevents lice eggs from hatching.
Therapeutic Effect(s):
Eradication of head lice.
Pharmacokinetics
Absorption: Some systemic absorption occurs following topical administration.
Distribution: Unknown.
Protein Binding: Abametapir– 92%; Abametapir carboxyl– 97%.
Metabolism and Excretion: Primarily metabolized by the liver by the CYP1A2 isoenzyme to an active metabolite, abametapir carboxyl. Excretion pathyway unknown.
Half-life: Abametapir carboxyl– 31–111 hr.
TIME/ACTION PROFILE (eradication of head lice)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
Topical | unknown | 24 hr | 2 wk |
Contraindication/Precautions
Contraindicated in:
- Pedi: Children <6 mo (↑ risk of benzyl alcohol absorption; benzyl alcohol may be associated with "gasping syndrome" in neonates and low birth weight infants.
Use Cautiously in:
- OB: Safety not established;
- Lactation: Safety not established.
Adverse Reactions/Side Effects
Derm: burning sensation, contact dermatitis, erythema, hair color changes, pruritus, rash
EENT: eye irritation
GI: vomiting
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Interactions
Drug-Drug
May ↑ levels and risk of toxicity of CYP1A2 substrates, CYP2B6 substrates, and CYP3A4 substrates ; avoid use of these medications within 2 wk of abemetapir administration.
Route/Dosage
Topical (Adults and Children ≥6 mo): Apply amount necessary to coat hair and scalp (up to 1 bottle), message thoroughly, leave in place for 10 minutes, then rinse with warm water.
Availability
Topical lotion (contains benzyl alcohol): 0.74%
Potential Diagnoses
- Activity intolerance
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