Calcium Channel Blocker Overdose
First Things First (assess & treat for the following):
- In 2004: 10,513 exposures, 62 fatalities
- Patient may present in shock or with severe bradydysrhythmias—institute ABCs and ACLS protocols as needed.
Physiology of calcium
- Myocardium
- Calcium enters myocardial cells via voltage-gated calcium channels.
- Entry triggers intracellular organelles to release calcium to affect excitation-contraction.
- Entry also triggers SA node action potential generation.
- Maintains fatty acid utilization by the myocardium
- Smooth Muscle: Calcium influx maintains tone
- Pancreas: Calcium mediates insulin release
Pathophysiology of calcium channel blockers
- Calcium channel blockers inhibit calcium entry by maintaining Ca channel in the closed position.
- In excess, calcium channel blockers cause toxicity characterized by bradycardia, conduction abnormalities and hypotension.
- Can produce a DKA-like state with insulin deficiency, hyperglycemia, acidemia and shock
- Also antagonize fast sodium channels, causing QRS prolongation
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Last updated: April 12, 2010
Citation
"Calcium Channel Blocker Overdose." Pocket ICU Management, PocketMedicine.com, Inc, 2010. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534151/all/Calcium_Channel_Blocker_Overdose.
Calcium Channel Blocker Overdose. Pocket ICU Management. PocketMedicine.com, Inc; 2010. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534151/all/Calcium_Channel_Blocker_Overdose. Accessed October 10, 2024.
Calcium Channel Blocker Overdose. (2010). In Pocket ICU Management. PocketMedicine.com, Inc. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534151/all/Calcium_Channel_Blocker_Overdose
Calcium Channel Blocker Overdose [Internet]. In: Pocket ICU Management. PocketMedicine.com, Inc; 2010. [cited 2024 October 10]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534151/all/Calcium_Channel_Blocker_Overdose.
* Article titles in AMA citation format should be in sentence-case
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T1 - Calcium Channel Blocker Overdose
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Y1 - 2010/04/12/
BT - Pocket ICU Management
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PB - PocketMedicine.com, Inc
DB - Anesthesia Central
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