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Drug-Induced Adverse Hepatic Interactions/Reactions

Drug-Induced Adverse Hepatic Interactions/Reactions is a topic covered in the Pocket ICU Management.

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Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. Explore these free sample topics:

Anesthesia Central

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First Things First (assess & treat for the following)

  • Does pt have evidence of fulminant hepatic failure or liver dysfunction that requires immediate attention?
    • Cerebral edema
      • Increased muscle tone
      • Abnormal pupillary reflexes
      • Decorticate/decerebrate posturing
      • Hypertension/bradycardia (Cushing’s reflex)
    • Hepatic encephalopathy
      • Stage III: stupor
      • Stage IV: coma
    • Coagulopathy w/ bleeding
      • PT >15 sec, PTT >50 sec
    • Thrombocytopenia w/ bleeding: platelets < 50,000
    • Circulatory collapse: mean arterial BP < 55 mmHg
      • Hemorrhage
      • Sepsis
    • Significant hypoglycemia < 80 mg/dL
    • Acute renal failure
    • Lactic acidosis pH < 7.25, lactate >2.5
    • Hepatopulmonary syndrome w/ hypoxemia PaO2< 55 mmHg
    • Pulmonary edema

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Last updated: May 20, 2010

Citation

"Drug-Induced Adverse Hepatic Interactions/Reactions." Pocket ICU Management, PocketMedicine.com, Inc, 2010. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/all/Drug_Induced_Adverse_Hepatic_Interactions_Reactions.
Drug-Induced Adverse Hepatic Interactions/Reactions. Pocket ICU Management. PocketMedicine.com, Inc; 2010. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/all/Drug_Induced_Adverse_Hepatic_Interactions_Reactions. Accessed June 15, 2019.
Drug-Induced Adverse Hepatic Interactions/Reactions. (2010). In Pocket ICU Management. Available from https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/all/Drug_Induced_Adverse_Hepatic_Interactions_Reactions
Drug-Induced Adverse Hepatic Interactions/Reactions [Internet]. In: Pocket ICU Management. PocketMedicine.com, Inc; 2010. [cited 2019 June 15]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/all/Drug_Induced_Adverse_Hepatic_Interactions_Reactions.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Drug-Induced Adverse Hepatic Interactions/Reactions ID - 534163 Y1 - 2010/05/20/ BT - Pocket ICU Management UR - https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/all/Drug_Induced_Adverse_Hepatic_Interactions_Reactions PB - PocketMedicine.com, Inc DB - Anesthesia Central DP - Unbound Medicine ER -