Drug-Induced Adverse Hepatic Interactions/Reactions
Drug-Induced Adverse Hepatic Interactions/Reactions is a topic covered in the Pocket ICU Management.
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First Things First (assess & treat for the following)
- Does pt have evidence of fulminant hepatic failure or liver dysfunction that requires immediate attention?
- Cerebral edema
- Increased muscle tone
- Abnormal pupillary reflexes
- Decorticate/decerebrate posturing
- Hypertension/bradycardia (Cushing’s reflex)
- Hepatic encephalopathy
- Stage III: stupor
- Stage IV: coma
- Coagulopathy w/ bleeding
- PT >15 sec, PTT >50 sec
- Thrombocytopenia w/ bleeding: platelets < 50,000
- Circulatory collapse: mean arterial BP < 55 mmHg
- Hemorrhage
- Sepsis
- Significant hypoglycemia < 80 mg/dL
- Acute renal failure
- Lactic acidosis pH < 7.25, lactate >2.5
- Hepatopulmonary syndrome w/ hypoxemia PaO2< 55 mmHg
- Pulmonary edema
- Cerebral edema
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Last updated: May 20, 2010
Citation
"Drug-Induced Adverse Hepatic Interactions/Reactions." Pocket ICU Management, PocketMedicine.com, Inc, 2010. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/all/Drug_Induced_Adverse_Hepatic_Interactions_Reactions.
Drug-Induced Adverse Hepatic Interactions/Reactions. Pocket ICU Management. PocketMedicine.com, Inc; 2010. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/all/Drug_Induced_Adverse_Hepatic_Interactions_Reactions. Accessed December 7, 2019.
Drug-Induced Adverse Hepatic Interactions/Reactions. (2010). In Pocket ICU Management. Available from https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/all/Drug_Induced_Adverse_Hepatic_Interactions_Reactions
Drug-Induced Adverse Hepatic Interactions/Reactions [Internet]. In: Pocket ICU Management. PocketMedicine.com, Inc; 2010. [cited 2019 December 07]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/all/Drug_Induced_Adverse_Hepatic_Interactions_Reactions.
* Article titles in AMA citation format should be in sentence-case
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T1 - Drug-Induced Adverse Hepatic Interactions/Reactions
ID - 534163
Y1 - 2010/05/20/
BT - Pocket ICU Management
UR - https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/all/Drug_Induced_Adverse_Hepatic_Interactions_Reactions
PB - PocketMedicine.com, Inc
DB - Anesthesia Central
DP - Unbound Medicine
ER -