Abciximab (ReoPro)
General
Glycoprotein IIb/IIIa inhibitor preventing platelet adhesion and aggregation.
Indications
Prevent thrombus formation peri–percutaneous transluminal coronary angioplasty (PTCA) and poststent placement.
Administration guidelines
- Standard concentration: 9 mg/250 mL 0.9% sodium chloride.
- The IV tubing must have a filter on it (0.2- or 0.22-μm low–protein-binding filter) and no other medications should be piggybacked through this line.
- Loading dose (straight drug): 0.25 mg/kg administered 10 to 60 minutes prior to percutaneous coronary intervention (PCI). Withdraw through the 0.2- or 0.22-μm low–protein-binding filter the appropriate amount of abciximab for the patient’s weight. Hypotension may occur with bolus dose.
- Maintenance at a rate of 0.125 μg/kg/min to a maximum of 10 μg/min (17 mL/h) for 12 hours. To prepare, withdraw 4.5 mL (9 mg) of abciximab through 0.2- or 0.22-μm low–protein-binding filter and inject into a 250-mL bag of 0.9% sodium chloride.
Citation
Pino, Richard M., editor. "Abciximab (ReoPro)." Clinical Anesthesia Procedures, 10th ed., Wolters Kluwer, 2022. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728001/all/Abciximab__Reopro_.
Abciximab (ReoPro). In: Pino RMR, ed. Clinical Anesthesia Procedures. Wolters Kluwer; 2022. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728001/all/Abciximab__Reopro_. Accessed July 17, 2025.
Abciximab (ReoPro). (2022). In Pino, R. M. (Ed.), Clinical Anesthesia Procedures (10th ed.). Wolters Kluwer. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728001/all/Abciximab__Reopro_
Abciximab (ReoPro) [Internet]. In: Pino RMR, editors. Clinical Anesthesia Procedures. Wolters Kluwer; 2022. [cited 2025 July 17]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728001/all/Abciximab__Reopro_.
* Article titles in AMA citation format should be in sentence-case
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T1 - Abciximab (ReoPro)
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BT - Clinical Anesthesia Procedures
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DB - Anesthesia Central
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