Specific Considerations with Renal Disease - Pharmacology and Renal Failure

Specific Considerations with Renal Disease - Pharmacology and Renal Failure is a topic covered in the Clinical Anesthesia Procedures.

To view the entire topic, please or purchase a subscription.

Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. Explore these free sample topics:

Anesthesia Central

-- The first section of this topic is shown below --

Many common anesthetic drugs may be affected by renal dysfunction due to changes in compartment volumes, electrolytes, pH (acidemia resulting in a higher percentage of nonionized drug), decreased serum protein concentration resulting in increased bioavailability of protein-bound drugs, and impaired biotransformation and rates of excretion (Table 4.5). Loading doses do not need to be altered significantly in CKD as the duration of action of drugs administered by bolus is determined by redistribution, not elimination. With repeated dosing or long-term infusion, the duration of action is dependent on elimination, and maintenance doses of drugs with significant renal excretion should be reduced.

-- To view the remaining sections of this topic, please or purchase a subscription --