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Specific Considerations with Renal Disease - Pharmacology and Renal Failure

Specific Considerations with Renal Disease - Pharmacology and Renal Failure is a topic covered in the Clinical Anesthesia Procedures.

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Many common anesthetic drugs may be affected by renal dysfunction due to changes in compartment volumes, electrolytes, pH (acidemia resulting in a higher percentage of nonionized drug), decreased serum protein concentration resulting in increased bioavailability of protein-bound drugs, and impaired biotransformation and rates of excretion (Table 4.5). Loading doses do not need to be altered significantly in CKD as the duration of action of drugs administered by bolus is determined by redistribution, not elimination. With repeated dosing or long-term infusion, the duration of action is dependent on elimination, and maintenance doses of drugs with significant renal excretion should be reduced.

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Citation

Pino, Richard M., editor. "Specific Considerations With Renal Disease - Pharmacology and Renal Failure." Clinical Anesthesia Procedures, 9th ed., Wolters Kluwer, 2019. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728141/all/Specific_Considerations_with_Renal_Disease___Pharmacology_and_Renal_Failure.
Specific Considerations with Renal Disease - Pharmacology and Renal Failure. In: Pino RM, ed. Clinical Anesthesia Procedures. 9th ed. Wolters Kluwer; 2019. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728141/all/Specific_Considerations_with_Renal_Disease___Pharmacology_and_Renal_Failure. Accessed March 22, 2019.
Specific Considerations with Renal Disease - Pharmacology and Renal Failure. (2019). In Pino, R. M. (Ed.), Clinical Anesthesia Procedures. Available from https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728141/all/Specific_Considerations_with_Renal_Disease___Pharmacology_and_Renal_Failure
Specific Considerations With Renal Disease - Pharmacology and Renal Failure [Internet]. In: Pino RM, editors. Clinical Anesthesia Procedures. Wolters Kluwer; 2019. [cited 2019 March 22]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728141/all/Specific_Considerations_with_Renal_Disease___Pharmacology_and_Renal_Failure.
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TY - ELEC T1 - Specific Considerations with Renal Disease - Pharmacology and Renal Failure ID - 728141 ED - Pino,Richard M, BT - Clinical Anesthesia Procedures UR - https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728141/all/Specific_Considerations_with_Renal_Disease___Pharmacology_and_Renal_Failure PB - Wolters Kluwer ET - 9 DB - Anesthesia Central DP - Unbound Medicine ER -