Clinical Anesthesia Procedures
Specific Considerations with Liver Disease - Hepatic Anatomy
Specific Considerations with Liver Disease - Hepatic Anatomy is a topic covered in the Clinical Anesthesia Procedures.
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Liver Structure
Liver Structure
- The anatomic unit of the liver is lobule. The lobule is composed of hexagonal plates of hepatocytes and portal triads (terminal portal vein, hepatic artery, and bile duct branch) surrounding a central hepatic vein.
- Hepatocytes are classified by their position in relation to their portal triad. Those closest to the triad are labeled Zone 1 cells (periportal). These cells receive the most oxygen and nutrients and are responsible for most nitrogen metabolism, oxidation, and gluconeogenesis. Zone 2 is a transitional area. Zone 3 hepatocytes (pericentral) are the farthest from the triad and are at the greatest risk for ischemic injury.
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Liver Structure
Liver Structure
- The anatomic unit of the liver is lobule. The lobule is composed of hexagonal plates of hepatocytes and portal triads (terminal portal vein, hepatic artery, and bile duct branch) surrounding a central hepatic vein.
- Hepatocytes are classified by their position in relation to their portal triad. Those closest to the triad are labeled Zone 1 cells (periportal). These cells receive the most oxygen and nutrients and are responsible for most nitrogen metabolism, oxidation, and gluconeogenesis. Zone 2 is a transitional area. Zone 3 hepatocytes (pericentral) are the farthest from the triad and are at the greatest risk for ischemic injury.
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Citation
Pino, Richard M., editor. "Specific Considerations With Liver Disease - Hepatic Anatomy." Clinical Anesthesia Procedures, 9th ed., Wolters Kluwer, 2019. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728144/all/Specific_Considerations_with_Liver_Disease___Hepatic_Anatomy.
Specific Considerations with Liver Disease - Hepatic Anatomy. In: Pino RMR, ed. Clinical Anesthesia Procedures. Wolters Kluwer; 2019. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728144/all/Specific_Considerations_with_Liver_Disease___Hepatic_Anatomy. Accessed March 23, 2023.
Specific Considerations with Liver Disease - Hepatic Anatomy. (2019). In Pino, R. M. (Ed.), Clinical Anesthesia Procedures (9th ed.). Wolters Kluwer. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728144/all/Specific_Considerations_with_Liver_Disease___Hepatic_Anatomy
Specific Considerations With Liver Disease - Hepatic Anatomy [Internet]. In: Pino RMR, editors. Clinical Anesthesia Procedures. Wolters Kluwer; 2019. [cited 2023 March 23]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728144/all/Specific_Considerations_with_Liver_Disease___Hepatic_Anatomy.
* Article titles in AMA citation format should be in sentence-case
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T1 - Specific Considerations with Liver Disease - Hepatic Anatomy
ID - 728144
ED - Pino,Richard M,
BT - Clinical Anesthesia Procedures
UR - https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728144/all/Specific_Considerations_with_Liver_Disease___Hepatic_Anatomy
PB - Wolters Kluwer
ET - 9
DB - Anesthesia Central
DP - Unbound Medicine
ER -
