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Intra-anesthetic Problems - Malignant Hyperthermia

Intra-anesthetic Problems - Malignant Hyperthermia is a topic covered in the Clinical Anesthesia Procedures.

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Etiology

Etiology. Malignant hyperthermia is a hypermetabolic syndrome occurring in genetically susceptible patients after exposure to an anesthetic triggering agent. Triggering anesthetics include all potent inhalational agents (e.g., halothane, isoflurane, desflurane, and sevoflurane) and succinylcholine. The syndrome is thought to be due to a reduction in the reuptake of Ca2+ by the sarcoplasmic reticulum necessary for the termination of muscle contraction. Consequently, muscle contraction is sustained, resulting in signs of hypermetabolism, including tachycardia, acidosis, hypercarbia, muscle rigidity, tachypnea, hypoxemia, and hyperthermia. Malignant hyperthermia usually occurs in the operating room but onset may be delayed until the patient reaches the postanesthesia care unit or even the postoperative floor.

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Citation

Pino, Richard M., editor. "Intra-anesthetic Problems - Malignant Hyperthermia." Clinical Anesthesia Procedures, 9th ed., Wolters Kluwer, 2019. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728256/all/Intra_anesthetic_Problems___Malignant_Hyperthermia.
Intra-anesthetic Problems - Malignant Hyperthermia. In: Pino RM, ed. Clinical Anesthesia Procedures. 9th ed. Wolters Kluwer; 2019. https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728256/all/Intra_anesthetic_Problems___Malignant_Hyperthermia. Accessed April 21, 2019.
Intra-anesthetic Problems - Malignant Hyperthermia. (2019). In Pino, R. M. (Ed.), Clinical Anesthesia Procedures. Available from https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728256/all/Intra_anesthetic_Problems___Malignant_Hyperthermia
Intra-anesthetic Problems - Malignant Hyperthermia [Internet]. In: Pino RM, editors. Clinical Anesthesia Procedures. Wolters Kluwer; 2019. [cited 2019 April 21]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728256/all/Intra_anesthetic_Problems___Malignant_Hyperthermia.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Intra-anesthetic Problems - Malignant Hyperthermia ID - 728256 ED - Pino,Richard M, BT - Clinical Anesthesia Procedures UR - https://anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728256/all/Intra_anesthetic_Problems___Malignant_Hyperthermia PB - Wolters Kluwer ET - 9 DB - Anesthesia Central DP - Unbound Medicine ER -