Intra-anesthetic Problems - Anaphylactic and Anaphylactoid Reactions
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Anaphylaxis is a life-threatening allergic reaction. It is initiated by antigen binding to preformed IgE antibodies on the surface of mast cells and basophils, which cause release of vasoactive substances (e.g., histamine, leukotrienes, prostaglandins, kinins, and platelet-activating factor). Anaphylaxis is characterized by an acute elevation in tryptase levels.