sage
General
Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.
Pronunciation:
seyj
Trade Name(s)
- Salvia officinalis
- common sage
- garden sage
Ther. Class.
anti-Alzheimers's agents
anti-infectives
Common Uses
- Alzheimer's disease.
- Herpes labialis.
Action
Sage leaf and volatile oil contain active constituents that have antioxidant, CNS depressant, estrogenic, anti-inflammatory and anticholinesterase activity. It may also have hypoglycemic activity. Sage also contains camphor which can cause neurotoxicity and hepatotoxicity in high doses.
Therapeutic Effect(s):
Improved cognitive function in Alzheimer's disease.
Pharmacokinetics
Absorption: Unknown
Distribution: Unknown
Metabolism and Excretion: Unknown
Half-life: Unknown
TIME/ACTION PROFILE
ONSET | PEAK | DURATION | |
---|---|---|---|
PO | unknown | unknown | unknown |
Contraindication/Precautions
Contraindicated in:
- Hypersensitivity;
- Pregnancy and lactation.
Use Cautiously in:
- Seizure disorders;
- Hypertension;
- Diabetes
Adverse Reactions/Side Effects
CV: hypertension
CNS: dizziness, agitation, seizures (high doses)
GI: nausea, vomiting, abdominal pain, hepatotoxicity (high doses)
Resp: wheezing
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Interactions
Natural Drug Interaction
- Additive effects with hypoglycemic agents and CNS depressants.
- May interfere with the effectiveness of anticonvulsants..
Natural-Natural:
Route/Dosage
PO (Adults): Alzheimer's disease– 1 gram/day of extract.
Topical (Adults): Herpes labialis– apply cream with 23 mg/gram of sage extract every 2–4 hours while awake starting within 1 day of the first symptoms and continuing for 10 to 14 days.
Availability
Extract:
Cream : 23 mg/gram sage extract in combination with rhubarb extract
Assessment
- Monitor BP periodically during therapy.
- Alzheimer's disease: Assess memory and cognitive function periodically during therapy.
- Herpes labialis: Assess lesions prior to and periodically during therapy.
Lab Test Considerations:
Monitor: blood glucose periodically during therapy.
Potential Diagnoses
- Deficient knowledge, related to disease process and medication regimen (Patient/Family/Teaching)
Implementation
- PO Administer as directed.
- Topical Apply to lesions every 2–4 hrs while awake.
Patient/Family Teaching
- Instruct patient how to take or administer sage.
- Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
- Advice female patient to avoid taking more than is in normal food intake. Notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Evaluation/Desired Outcomes
- Improved cognitive function in patients with Alzheimer's disease.
- Healing of lesions in herpes labialis.
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