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Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.


Trade Name(s)

  • all-trans lycopene
  • psi-psi-carotene

Ther. Class.
cardioprotective agents

Common Uses

  • Atherosclerosis prevention.
  • Exercise-induced asthma.
  • Cancer prevention.
  • Oral leukoplakia.


Lycopene is a predominant carotenoid in blood and tissues that has antioxidant properties. It scavenges free radicals and prevents oxidative damage to DNA. It may decrease cholesterol synthesis and remove LDL cholesterol from circulation. 85% of dietary lycopene comes from tomato-derived products.

Therapeutic Effect(s):

  • Atherosclerosis prevention.
  • Cancer prevention.


Absorption: Unknown

Distribution: Unknown

Metabolism and Excretion: Unknown

Half-life: Unknown




Contraindicated in:

  • Hypersensitivity.

Use Cautiously in:

Pregnancy and lactation (when using amounts greater than those found in foods)

Adverse Reactions/Side Effects

GI: diarrhea, abdominal pain, flatulence

* CAPITALS indicate life-threatening.
Underline indicate most frequent.


Natural Drug Interaction



Absorption may be increased with beta carotene .


PO: (Adults) Exercise-induced asthma– 30 mg/day; Prostate cancer– 15 mg twice daily;Oral leukoplakia– 4–8 mg/day.


Softgels: 10 mg, 15 mg, 20 mg


  • Monitor for GI side effects (abdominal pain, flatus, diarrhea) periodically during therapy.

Lab Test Considerations:

Monitor lipid profile, serum androgen, and Prostate Specific Antigen (PSA) before and periodically during therapy.

Potential Diagnoses


  • PO: Administer as directed.

Patient/Family Teaching

  • Instruct patient to take as directed.
  • Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

Decrease in atherosclerosis and exercise–induced asthma.

lycopene is a sample topic from the Davis's Drug Guide.

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Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. Learn more.


Quiring, Courtney, et al. "Lycopene." Davis's Drug Guide, 16th ed., F.A. Davis Company, 2019. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109943/all/lycopene.
Quiring C, Sanoski CA, Vallerand AH. Lycopene. Davis's Drug Guide. 16th ed. F.A. Davis Company; 2019. https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109943/all/lycopene. Accessed April 18, 2019.
Quiring, C., Sanoski, C. A., & Vallerand, A. H. (2019). Lycopene. In Davis's Drug Guide. Available from https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109943/all/lycopene
Quiring C, Sanoski CA, Vallerand AH. Lycopene [Internet]. In: Davis's Drug Guide. F.A. Davis Company; 2019. [cited 2019 April 18]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109943/all/lycopene.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - lycopene ID - 109943 A1 - Quiring,Courtney, AU - Sanoski,Cynthia A, AU - Vallerand,April Hazard, BT - Davis's Drug Guide UR - https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109943/all/lycopene PB - F.A. Davis Company ET - 16 DB - Anesthesia Central DP - Unbound Medicine ER -