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saccharomyces boulardii


Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

sak-a-roe-mye-seez boo-lar-dee

Trade Name(s)

  • Brewer's yeast
  • probiotics

Ther. Class.
anti irritable bowel syndrome agents

Common Uses

  • Treatment and prevention of diarrhea
  • Irritable bowel syndrome.


Saccharomyces boulardii is a non-pathogenic yeast used to colonize the gastrointestinal tract.

Therapeutic Effect(s):

Reduced number of bowel movements.


Absorption: Unknown

Distribution: Unknown

Metabolism and Excretion: Unknown

Half-life: Unknown


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Contraindicated in:

  • Hypersensitivity to yeast.

Use Cautiously in:

  • Pregnancy and lactation;
  • Immunocompromised patients (↑ risk of fungemia)

Adverse Reactions/Side Effects

GI: bloating, constipation, flatulence

Misc: fungemia, ↑ thirst

* CAPITALS indicate life-threatening.
Underline indicate most frequent.


Natural Drug Interaction

Antifungalsmay decrease effectiveness of Saccharomyces boulardii




PO: (Adults) 250–500 mg two to four times a day.


Capsules: 250 mg


  • Assess patient for abdominal distention, presence of bowel sounds, and usual pattern of bowel function.
  • Assess color, consistency, and amount of stool produced.

Lab Test Considerations:

Monitor CBC periodically during therapy.

Potential Diagnoses

  • Diarrhea (Indications)


  • PO: Administer as directed.

Patient/Family Teaching

  • Instruct patient to take as directed.
  • Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

Resolution of diarrhea and decrease in number of loose stools.

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Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. Learn more.


Quiring, Courtney, et al. "Saccharomyces Boulardii." Davis's Drug Guide, 16th ed., F.A. Davis Company, 2019. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109984/all/saccharomyces_boulardii.
Quiring C, Sanoski CA, Vallerand AH. Saccharomyces boulardii. Davis's Drug Guide. 16th ed. F.A. Davis Company; 2019. https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109984/all/saccharomyces_boulardii. Accessed April 26, 2019.
Quiring, C., Sanoski, C. A., & Vallerand, A. H. (2019). Saccharomyces boulardii. In Davis's Drug Guide. Available from https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109984/all/saccharomyces_boulardii
Quiring C, Sanoski CA, Vallerand AH. Saccharomyces Boulardii [Internet]. In: Davis's Drug Guide. F.A. Davis Company; 2019. [cited 2019 April 26]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109984/all/saccharomyces_boulardii.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - saccharomyces boulardii ID - 109984 A1 - Quiring,Courtney, AU - Sanoski,Cynthia A, AU - Vallerand,April Hazard, BT - Davis's Drug Guide UR - https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/109984/all/saccharomyces_boulardii PB - F.A. Davis Company ET - 16 DB - Anesthesia Central DP - Unbound Medicine ER -