hydrogen peroxide


hye-droe-jen per-oks-ide

Trade Name(s)

  • Eskata

Ther. Class.


Seborrheic keratoses (raised).


Mechanism of action for treatment of seborrheic keratoses unknown.

Therapeutic Effect(s):

Resolution of seborrheic keratoses lesions.


Absorption: No systemic absorption following topical application.

Distribution: Unknown.

Metabolism and Excretion: Unknown.

Half-life: Unknown.




Contraindicated in:

  • None.

Use Cautiously in:

OB:  Safety and effectiveness not established in pregnancy.

Adverse Reactions/Side Effects

Derm: crusting, erosion, erythema, hyperpigmentation, hypopigmentation, pruritus, scaling, stinging, vesiculation, scarring, ulceration

* CAPITALS indicate life-threatening.
Underline indicate most frequent.



None known.


Topical (Adults): Apply to lesions 4 times, 1 minute apart, during a single in-office treatment session. May repeat if the treated lesions have not completely cleared 3 weeks after treatment.


Topical solution: 40%


  • Assess skin lesions prior to and periodically following therapy.
  • Monitor for skin reactions (erosion, ulceration, vesiculation, scarring) following application. Do not attempt 2nd application until skin reactions have recovered.

Potential Diagnoses


  • Medication is applied by health care professional. Do not apply to open or infected seborrheic keratosis. Clean lesions with alcohol to ensure free of oil and debris before application. Using applicator, apply solution directly to the seborrheic keratosis in a circular motion 4 times, approximately 1 min apart. Apply enough solution to uniformly wet lesion surface, including edges without excess running or dripping. Avoid eyes during application to facial lesions. If lesions remain 3 wks after treatment, may be reapplied.

Patient/Family Teaching

  • Explain purpose of medication to patient.
  • Inform patients that severe eye injury can occur with application. Advise patient to inform health care provider immediately if medication runs into eyes, mouth, or nose during administration.
  • Advise patient that local skin reactions may occur following treatment.

Evaluation/Desired Outcomes

Resolution of seborrheic keratoses lesions.

hydrogen peroxide is a sample topic from the Davis's Drug Guide.

To view other topics, please or .

Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. .