Guide to Diagnostic Tests
AUTOANTIBODIES: FREQUENCY (%) OF AUTOANTIBODIES IN RHEUMATIC DISEASES
| ANA | Anti- dsDNA | Rheumatoid Factor | Anti-Sm | Anti-SS-A | Anti-SS-B | Anti-SCL-70 | Anti-Centromere | Anti-Jo-1 | ANCA | Anti-CCP | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | 30–60 | 0–5 | 70 | 0 | 0–5 | 0–2 | 0 | 0 | 0 | 0 | 70-80 |
| Systemic lupus erythematosus | 95–100 | 60 | 20 | 10–25 | 15–20 | 5–20 | 0 | 0 | 0 | 0–1 | 30-702 |
| Sjögren syndrome | 95 | 0 | 75 | 0 | 65 | 65 | 0 | 0 | 0 | 0 | 0 |
| Diffuse scleroderma | 80–95 | 0 | 30 | 0 | 0 | 0 | 33 | 1 | 0 | 0 | 0 |
| Limited scleroderma (CREST syndrome) | 80–95 | 0 | 30 | 0 | 0 | 0 | 20 | 50 | 0 | 0 | 0 |
| Polymyositis/dermatomyositis | 80–95 | 0 | 33 | 0 | 0 | 0 | 0 | 0 | 20–30 | 0 | 0 |
| Granulomatosis with polyangiitis | 0–15 | 0 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 93–961 | 0 |
1Frequency for generalized, active disease.2 Frequency for SLE with deforming erosive arthritis.
Anti-dsDNA = anti-double-stranded DNA antibody; ANA = antinuclear antibodies; ANCA = antineutrophil cytoplasmic antibody; Anti-CCP = antibodies to cyclic citrullinated peptide; Anti-Jo-1 = antibodies directed against histidyl-tRNA synthetase; Anti-Sm = anti-Smith antibody; Anti-SCL-70 = anti-scleroderma antibody; Anti-SSA = antibodies to Ro (SSA) cellular ribonucleoprotein complexes of two types (52 kDa and 60 kDa); Anti-SSB = antibodies to La (SSB) cellular ribonucleoprotein complexes; CREST = C alcinosis cutis, R aynaud phenomenon, E sophageal motility disorder, S clerodactyly, and T elangiectasia.
Reproduced with permission from Papadakis MA, McPhee SJ, Rabow MW (editors). Current Medical Diagnosis & Treatment 2016, 55th ed., McGraw-Hill, 2016.
Citation
Nicoll, Diana, et al. "AUTOANTIBODIES: FREQUENCY (%) of AUTOANTIBODIES in RHEUMATIC DISEASES." Guide to Diagnostic Tests, 7th ed., McGraw-Hill Education, 2017. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/GDT/619496/all/AUTOANTIBODIES:_FREQUENCY_____OF_AUTOANTIBODIES_IN_RHEUMATIC_DISEASES.
Nicoll DD, Lu CMC, McPhee SJS. AUTOANTIBODIES: FREQUENCY (%) OF AUTOANTIBODIES IN RHEUMATIC DISEASES. Guide to Diagnostic Tests. McGraw-Hill Education; 2017. https://anesth.unboundmedicine.com/anesthesia/view/GDT/619496/all/AUTOANTIBODIES:_FREQUENCY_____OF_AUTOANTIBODIES_IN_RHEUMATIC_DISEASES. Accessed May 14, 2025.
Nicoll, D., Lu, C. M., & McPhee, S. J. (2017). AUTOANTIBODIES: FREQUENCY (%) OF AUTOANTIBODIES IN RHEUMATIC DISEASES. In Guide to Diagnostic Tests (7th ed.). McGraw-Hill Education. https://anesth.unboundmedicine.com/anesthesia/view/GDT/619496/all/AUTOANTIBODIES:_FREQUENCY_____OF_AUTOANTIBODIES_IN_RHEUMATIC_DISEASES
Nicoll DD, Lu CMC, McPhee SJS. AUTOANTIBODIES: FREQUENCY (%) of AUTOANTIBODIES in RHEUMATIC DISEASES [Internet]. In: Guide to Diagnostic Tests. McGraw-Hill Education; 2017. [cited 2025 May 14]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/GDT/619496/all/AUTOANTIBODIES:_FREQUENCY_____OF_AUTOANTIBODIES_IN_RHEUMATIC_DISEASES.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - AUTOANTIBODIES: FREQUENCY (%) OF AUTOANTIBODIES IN RHEUMATIC DISEASES
ID - 619496
A1 - Lu,Chuanyi Mark,
AU - Nicoll,Diana,
AU - McPhee,Stephen J,
BT - Guide to Diagnostic Tests
UR - https://anesth.unboundmedicine.com/anesthesia/view/GDT/619496/all/AUTOANTIBODIES:_FREQUENCY_____OF_AUTOANTIBODIES_IN_RHEUMATIC_DISEASES
PB - McGraw-Hill Education
ET - 7
DB - Anesthesia Central
DP - Unbound Medicine
ER -
