Guillain-Barré Syndrome: A Demyelination Syndrome

Guillain-Barré Syndrome: A Demyelination Syndrome is a topic covered in the Pocket ICU Management.

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Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. Explore these free sample topics:

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First Things First (assess for & treat the following)

  • In pts w/ acute paraparesis or quadriparesis evaluate for:
    • Myelopathy (spinal cord lesion)
      • Myelitis
      • Spinal cord compression
    • Peripheral nervous system (PNS) disorders
      • Guillain-Barré syndrome (GBS), particularly acute inflammatory demyelinating polyneuropathy (AIDP)
      • Mononeuropathy multiplex (vasculitis of PNS)
      • Acute intermittent porphyria
      • Acute critical illness neuropathy
      • Lumbosacral polyradiculopathy (cauda equina syndrome)
    • Neuromuscular junction disorders
      • Presynaptic
        • Botulism
        • Tick paralysis
        • Organophosphate poisoning
        • Drug-induced myasthenia gravis
      • Postsynaptic
        • Myasthenia gravis (myasthenic crisis)
    • Myopathy
      • Acute inflammatory myopathy (polymyositis or dermatomyositis)
      • Acute infectious myositis
      • Acute toxic/drug-induced myositis
      • Hypo- or hyperkalemic periodic paralysis
  • If pt felt to have GBS:
    • Assess for & treat respiratory distress (dyspnea, orthopnea)
      • 30% of pts require intubation and mechanical ventilation.
      • Maintain head of bed > 30°
      • Obtain forced vital capacity (FVC) & negative inspiratory force (NIF)
    • Assess for & treat cardiac arrhythmias (ECG monitor), labile BP

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Last updated: April 27, 2010