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Methemoglobinemia is a topic covered in the Pocket ICU Management.

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Anesthesia Central

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First Things First

  • Cyanosis in the face of normal PaO2 is key item.
  • Tissue dysoxia and hypoxia cause the deleterious signs/symptoms seen.
  • This state causes significant tissue hypoxia, cyanosis and oxidative stress.
  • This stressful oxidative state can also lead to hemolysis.
  • Supportive treatment
    • High-concentration FiO2 to saturate remaining normal HgG
    • In symptomatic pts, consider methylene blue (see below).
    • Most patients respond within 15-30 minutes.
  • Poison control is a good resource for management.

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Last updated: May 9, 2010


"Methemoglobinemia." Pocket ICU Management, PocketMedicine.com, Inc, 2010. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534069/all/Methemoglobinemia.
Methemoglobinemia. Pocket ICU Management. PocketMedicine.com, Inc; 2010. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534069/all/Methemoglobinemia. Accessed April 18, 2019.
Methemoglobinemia. (2010). In Pocket ICU Management. Available from https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534069/all/Methemoglobinemia
Methemoglobinemia [Internet]. In: Pocket ICU Management. PocketMedicine.com, Inc; 2010. [cited 2019 April 18]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534069/all/Methemoglobinemia.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Methemoglobinemia ID - 534069 Y1 - 2010/05/09/ BT - Pocket ICU Management UR - https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534069/all/Methemoglobinemia PB - PocketMedicine.com, Inc DB - Anesthesia Central DP - Unbound Medicine ER -