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Carbon Monoxide Poisoning

Carbon Monoxide Poisoning is a topic covered in the Pocket ICU Management.

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Anesthesia Central

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First Things First (assess & treat for the following)

  • Carbon monoxide
    • Immediate removal from contaminated area
    • ABCs (airway, breathing, circulation)
    • Assess fire victims for airway obstruction, thermal injury, cyanide intoxication, myocardial ischemia, conduction defects.
    • Administer 100% oxygen immediately for management; for some, hyperbaric O2 may be indicated if available.
  • Tissue hypoxia is the primary problem.
  • Mechanisms:
    • Carbon monoxide (CO) binds to hemoglobin with an affinity 250 times that of oxygen, resulting in reduced oxyhemoglobin saturation and decreased blood oxygen-carrying capacity.
    • Also, the oxyhemoglobin dissociation curve is displaced to the left, impairing oxygen delivery at the tissues.
    • CO may also directly inhibit cytochrome oxidase, further disrupting cellular function.
    • CO is known to bind to myoglobin, possibly contributing to impaired myocardial contractility.

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Last updated: April 12, 2010


"Carbon Monoxide Poisoning." Pocket ICU Management, PocketMedicine.com, Inc, 2010. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534086/all/Carbon_Monoxide_Poisoning.
Carbon Monoxide Poisoning. Pocket ICU Management. PocketMedicine.com, Inc; 2010. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534086/all/Carbon_Monoxide_Poisoning. Accessed March 23, 2019.
Carbon Monoxide Poisoning. (2010). In Pocket ICU Management. Available from https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534086/all/Carbon_Monoxide_Poisoning
Carbon Monoxide Poisoning [Internet]. In: Pocket ICU Management. PocketMedicine.com, Inc; 2010. [cited 2019 March 23]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534086/all/Carbon_Monoxide_Poisoning.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Carbon Monoxide Poisoning ID - 534086 Y1 - 2010/04/12/ BT - Pocket ICU Management UR - https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534086/all/Carbon_Monoxide_Poisoning PB - PocketMedicine.com, Inc DB - Anesthesia Central DP - Unbound Medicine ER -