Tricyclic Antidepressant Overdose
First Things First (assess for and treat the following)
- ABCs are priority!
- Mental status may deteriorate; pts may need intubation.
- Cardiovascular monitoring for and treatment of life-threatening ventricular arrhythmias
- Refractory hypotension is the most common cause of death in TCA overdose; IV fluid resuscitation should be initiated and adequate IV access obtained.
- Activated charcoal should be administered for decontamination.
- Alkalinization with sodium bicarbonate is a cornerstone of therapy, especially if QRS >100 ms and pt has wide complex tachycardia or hypotension.
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Last updated: May 16, 2010
Citation
"Tricyclic Antidepressant Overdose." Pocket ICU Management, PocketMedicine.com, Inc, 2010. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534128/all/Tricyclic_Antidepressant_Overdose.
Tricyclic Antidepressant Overdose. Pocket ICU Management. PocketMedicine.com, Inc; 2010. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534128/all/Tricyclic_Antidepressant_Overdose. Accessed October 11, 2024.
Tricyclic Antidepressant Overdose. (2010). In Pocket ICU Management. PocketMedicine.com, Inc. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534128/all/Tricyclic_Antidepressant_Overdose
Tricyclic Antidepressant Overdose [Internet]. In: Pocket ICU Management. PocketMedicine.com, Inc; 2010. [cited 2024 October 11]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534128/all/Tricyclic_Antidepressant_Overdose.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Tricyclic Antidepressant Overdose
ID - 534128
Y1 - 2010/05/16/
BT - Pocket ICU Management
UR - https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534128/all/Tricyclic_Antidepressant_Overdose
PB - PocketMedicine.com, Inc
DB - Anesthesia Central
DP - Unbound Medicine
ER -