Graft-Versus-Host Transplant Immunology

Graft-Versus-Host Transplant Immunology is a topic covered in the Pocket ICU Management.

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First Things First (assess & treat for the following)

  • 50% of allogeneic BMT patients develop acute or chronic graft versus host disease (GVHD) of variable severity.
  • GVHD = donor’s bone marrow attacks the patient’s organs and tissues, leading to organ dysfunction and a worsened immunocompromised state
  • Acute GVHD usually develops < 100 days after allogeneic BMT.
  • Chronic GVHD usually develops >100 days after allogeneic BMT.
  • The incidence of both types of GVHD increases with patient age.

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Last updated: April 28, 2010