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Stress Ulcer Prophylaxis

Stress Ulcer Prophylaxis is a topic covered in the Pocket ICU Management.

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First Things First (assess & treat for the following)

  • Superficial lesions in the gastric mucosal layer secondary to major stressful events
  • Similar to NSAID-induced ulcerations but usually involve multiple sites
  • Multifactorial pathogenesis
    • Acid hypersecretion
    • Decreased mucus production
    • Decreased epithelial turnover
    • Reduction in blood flow
  • Major risk factors for development of stress ulcers include:
    • Respiratory failure requiring mechanical ventilation >48 hr
    • Coagulopathy
      • Platelets <50,000/mm3, INR >1.5 or aPTT >2 times control
      • Includes medication-induced (heparin, warfarin, etc.)
  • Minor risk factors for development of stress ulcers include:
    • Sepsis
    • Trauma
    • Acute organ failure
      • Renal insufficiency
      • Hepatic failure
    • Thermal injury
    • Lack of enteral feeding
    • Prolonged ICU admission

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Last updated: May 5, 2010


"Stress Ulcer Prophylaxis." Pocket ICU Management, PocketMedicine.com, Inc, 2010. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534133/all/Stress_Ulcer_Prophylaxis.
Stress Ulcer Prophylaxis. Pocket ICU Management. PocketMedicine.com, Inc; 2010. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534133/all/Stress_Ulcer_Prophylaxis. Accessed April 18, 2019.
Stress Ulcer Prophylaxis. (2010). In Pocket ICU Management. Available from https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534133/all/Stress_Ulcer_Prophylaxis
Stress Ulcer Prophylaxis [Internet]. In: Pocket ICU Management. PocketMedicine.com, Inc; 2010. [cited 2019 April 18]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534133/all/Stress_Ulcer_Prophylaxis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Stress Ulcer Prophylaxis ID - 534133 Y1 - 2010/05/05/ BT - Pocket ICU Management UR - https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534133/all/Stress_Ulcer_Prophylaxis PB - PocketMedicine.com, Inc DB - Anesthesia Central DP - Unbound Medicine ER -