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Diabetes Insipidus

Diabetes Insipidus is a topic covered in the Pocket ICU Management.

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First Things First (assess & treat for the following)

  • Water & sodium disorders CANNOT be separated from each other.
  • Any statement concerning regulation of water will involve disturbance of sodium concentration & vice versa.
  • Regardless of the current sodium concentration, symptomatic fluid deficits (hypovolemia) should be corrected urgently using an isotonic fluid such as lactated Ringer’s or normal saline.
  • The cause of DI is lack of ADH (central DI) or lack of ADH effect (nephrogenic DI).
  • Virtually any CNS disorder can lead to central or neurogenic DI.
  • If pt is taking lithium (or has anytime, especially if recently), then the pt has a component of DI (lithium-induced nephrogenic DI [LINDI]).
  • The “classic” findings include polydipsia, polyuria (>30 mL/kg/d), volume depletion & hypernatremia, w/ hyperosmolar serum despite hypo-osmolar urine.

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Last updated: April 26, 2010


"Diabetes Insipidus." Pocket ICU Management, PocketMedicine.com, Inc, 2010. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534147/all/Diabetes_Insipidus.
Diabetes Insipidus. Pocket ICU Management. PocketMedicine.com, Inc; 2010. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534147/all/Diabetes_Insipidus. Accessed April 18, 2019.
Diabetes Insipidus. (2010). In Pocket ICU Management. Available from https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534147/all/Diabetes_Insipidus
Diabetes Insipidus [Internet]. In: Pocket ICU Management. PocketMedicine.com, Inc; 2010. [cited 2019 April 18]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534147/all/Diabetes_Insipidus.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Diabetes Insipidus ID - 534147 Y1 - 2010/04/26/ BT - Pocket ICU Management UR - https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534147/all/Diabetes_Insipidus PB - PocketMedicine.com, Inc DB - Anesthesia Central DP - Unbound Medicine ER -