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Drug-Induced Adverse Hepatic Interactions/Reactions

Drug-Induced Adverse Hepatic Interactions/Reactions is a topic covered in the Pocket ICU Management.

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Anesthesia Central

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First Things First (assess & treat for the following)

  • Does pt have evidence of fulminant hepatic failure or liver dysfunction that requires immediate attention?
    • Cerebral edema
      • Increased muscle tone
      • Abnormal pupillary reflexes
      • Decorticate/decerebrate posturing
      • Hypertension/bradycardia (Cushing’s reflex)
    • Hepatic encephalopathy
      • Stage III: stupor
      • Stage IV: coma
    • Coagulopathy w/ bleeding
      • PT >15 sec, PTT >50 sec
    • Thrombocytopenia w/ bleeding: platelets < 50,000
    • Circulatory collapse: mean arterial BP < 55 mmHg
      • Hemorrhage
      • Sepsis
    • Significant hypoglycemia < 80 mg/dL
    • Acute renal failure
    • Lactic acidosis pH < 7.25, lactate >2.5
    • Hepatopulmonary syndrome w/ hypoxemia PaO2< 55 mmHg
    • Pulmonary edema

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Last updated: May 20, 2010


"Drug-Induced Adverse Hepatic Interactions/Reactions." Pocket ICU Management, PocketMedicine.com, Inc, 2010. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/4/Drug_Induced_Adverse_Hepatic_Interactions_Reactions.
Drug-Induced Adverse Hepatic Interactions/Reactions. Pocket ICU Management. PocketMedicine.com, Inc; 2010. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/4/Drug_Induced_Adverse_Hepatic_Interactions_Reactions. Accessed June 15, 2019.
Drug-Induced Adverse Hepatic Interactions/Reactions. (2010). In Pocket ICU Management. Available from https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/4/Drug_Induced_Adverse_Hepatic_Interactions_Reactions
Drug-Induced Adverse Hepatic Interactions/Reactions [Internet]. In: Pocket ICU Management. PocketMedicine.com, Inc; 2010. [cited 2019 June 15]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/4/Drug_Induced_Adverse_Hepatic_Interactions_Reactions.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Drug-Induced Adverse Hepatic Interactions/Reactions ID - 534163 Y1 - 2010/05/20/ BT - Pocket ICU Management UR - https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534163/4/Drug_Induced_Adverse_Hepatic_Interactions_Reactions PB - PocketMedicine.com, Inc DB - Anesthesia Central DP - Unbound Medicine ER -