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Lithium Overdose

Lithium Overdose is a topic covered in the Pocket ICU Management.

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First Things First

  • Metal similar to potassium, magnesium and sodium
  • Currently used in treatment of bipolar disorder for the mania and as a mood stabilizer
  • Narrow toxic-to-therapeutic range ratio
  • Tablets and capsules
    • 300-mg tablets have 8 mEq of lithium
    • Also comes in 150-mg and 600-mg capsules
    • Extended release, 300 mg, 450 mg
    • Syrup has 8 mEq/5 mL.
    • Normal serum level is 0.7-1.2 mEq/L.
  • Mechanism of action is not well understood.
    • May stabilize cell membranes
    • Inhibits NE to interfere with cAMP
    • Enhances effects of serotonin
    • Rapidly absorbed into serum from GI tract and therefore peaks rapidly
    • Syrup: 40 min
    • Rapid release: 2-4 hr
    • Extended release: 4-12 hrs
  • Renal elimination 95%
    • Sweat/saliva/milk: 5%
    • Prolonged & delayed absorption
    • Decreased elimination
    • Intracellular lithium build-up
  • It is not metabolized.
    • No protein binding
    • We reabsorb more when we are in a low-sodium or low-volume state.
  • Lithium modulates signals affecting the cytoskeleton, thereby stabilizing moods.

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Last updated: April 28, 2010


"Lithium Overdose." Pocket ICU Management, PocketMedicine.com, Inc, 2010. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534168/all/Lithium_Overdose.
Lithium Overdose. Pocket ICU Management. PocketMedicine.com, Inc; 2010. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534168/all/Lithium_Overdose. Accessed April 23, 2019.
Lithium Overdose. (2010). In Pocket ICU Management. Available from https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534168/all/Lithium_Overdose
Lithium Overdose [Internet]. In: Pocket ICU Management. PocketMedicine.com, Inc; 2010. [cited 2019 April 23]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534168/all/Lithium_Overdose.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Lithium Overdose ID - 534168 Y1 - 2010/04/28/ BT - Pocket ICU Management UR - https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534168/all/Lithium_Overdose PB - PocketMedicine.com, Inc DB - Anesthesia Central DP - Unbound Medicine ER -