Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. Explore these free sample topics:
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First Things First
- Metal similar to potassium, magnesium and sodium
- Currently used in treatment of bipolar disorder for the mania and as a mood stabilizer
- Narrow toxic-to-therapeutic range ratio
- Tablets and capsules
- 300-mg tablets have 8 mEq of lithium
- Also comes in 150-mg and 600-mg capsules
- Extended release, 300 mg, 450 mg
- Syrup has 8 mEq/5 mL.
- Normal serum level is 0.7-1.2 mEq/L.
- Mechanism of action is not well understood.
- May stabilize cell membranes
- Inhibits NE to interfere with cAMP
- Enhances effects of serotonin
- Rapidly absorbed into serum from GI tract and therefore peaks rapidly
- Syrup: 40 min
- Rapid release: 2-4 hr
- Extended release: 4-12 hrs
- Renal elimination 95%
- Sweat/saliva/milk: 5%
- Prolonged & delayed absorption
- Decreased elimination
- Intracellular lithium build-up
- It is not metabolized.
- No protein binding
- We reabsorb more when we are in a low-sodium or low-volume state.
- Lithium modulates signals affecting the cytoskeleton, thereby stabilizing moods.