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Drug-Induced Hematologic Disorders

Drug-Induced Hematologic Disorders is a topic covered in the Pocket ICU Management.

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First Things First (assess & treat for the following)

  • These side effects can occur in the marrow or systemically, and hematologic effects of drugs can be mediated by one or many factors.
  • Dysfunction can range in severity from mild to severe, and the clinical picture is variable.
  • Hemolysis is usually not severe, but life-threatening cases do occur, esp. in pts with comorbid conditions.
  • Some drug-induced disorders may occur weeks to years after use.
  • Suspect cephalosporin- or quinidine-induced hemolytic anemia if acute, severe hemolysis occurs with renal failure.
  • Diagnostic tests are not always specific; usually the diagnosis made with history, physical & removal of suspected drug.
  • Suspect drug-induced hemolytic anemia if:
    • Anemia, fevers, rash, renal failure develop when drug started
    • Hemolytic indices are seen:
      • Anemia, cytopenias
      • Reticulocytosis
      • Increased LDH
      • Decreased haptoglobin
    • Increased indirect bilirubin
    • Hemoglobinuria
  • Discontinue any new drug that may be responsible for a recent change in pt’s condition.

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Last updated: May 10, 2010

Citation

"Drug-Induced Hematologic Disorders." Pocket ICU Management, PocketMedicine.com, Inc, 2010. Anesthesia Central, anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534237/all/Drug_Induced_Hematologic_Disorders.
Drug-Induced Hematologic Disorders. Pocket ICU Management. PocketMedicine.com, Inc; 2010. https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534237/all/Drug_Induced_Hematologic_Disorders. Accessed April 20, 2019.
Drug-Induced Hematologic Disorders. (2010). In Pocket ICU Management. Available from https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534237/all/Drug_Induced_Hematologic_Disorders
Drug-Induced Hematologic Disorders [Internet]. In: Pocket ICU Management. PocketMedicine.com, Inc; 2010. [cited 2019 April 20]. Available from: https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534237/all/Drug_Induced_Hematologic_Disorders.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Drug-Induced Hematologic Disorders ID - 534237 Y1 - 2010/05/10/ BT - Pocket ICU Management UR - https://anesth.unboundmedicine.com/anesthesia/view/Pocket-ICU-Management/534237/all/Drug_Induced_Hematologic_Disorders PB - PocketMedicine.com, Inc DB - Anesthesia Central DP - Unbound Medicine ER -