Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. Explore these free sample topics:
-- The first section of this topic is shown below --
First Things First
- SIADH is a disorder of excess and inappropriate ADH, leading to retention of excess water in the body, usually creating the cardinal combination of hyponatremia with volume overload. All disorders of sodium MUST be evaluated in terms of both water and sodium.
- SIADH is usually not life-threatening unless significant metabolic encephalopathy and/or seizures develop. If these neurologic complications are present, more aggressive correction of serum sodium to 125 mEq/L may be appropriate.
- Na deficit (mEq) = 0.6 × ideal body weight × (125 - current plasma sodium concentration)
- Another diagnosis that closely mimics SIADH is the so-called “cerebral salt wasting” syndrome (CSW), which commonly found in neurosurgical disorders, including subarachnoid hemorrhage.
- CSW is inappropriate urinary excretion of sodium, usually accompanied with volume loss, and thus should be considered in patients with hyponatremia and evidence of volume depletion.