Significant preoperative, intraoperative, and postoperative concerns must be considered in this patient population. Bone, cartilage, and soft tissue malignancy can occur in every age group. Over the past 3 decades, aggressive surgical treatment and creative reconstructive techniques have revolutionized care, and limb salvage is a reality for many patients. Orthopedic malignancies include primary tumors—osteogenic sarcoma, chondrosarcoma, and Ewing sarcoma—and metastatic tumors, which are usually breast, prostate, and melanoma cancers.