Acute Hemolytic Anemia
Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. This collection of drug, procedures and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and MEDLINE Journals. Explore these free sample topics:
-- The first section of this topic is shown below --
First Things First (assess & treat for the following)
- Characterized by premature RBC destruction greater than increased RBC production (erythrocytosis), spherocytosis without bleeding
- Most cases are caused by extrinsic factors: drugs, exogenous antibodies, mechanical trauma, infections & toxins.
- 50% of cases are idiopathic or primary and not associated with pre-existing disease.
- Autoimmune hemolytic anemia has shortened RBC lifespan with positive Coombs’ test.
- ≥80% of cases are of warm reactive autoantibodies of IgG subclass; the rest are cold reactive.
- Hemolysis occurs when nonphagocytized RBCs take on a spherical shape, rendering them poorly deformable and rigid.
- These acquired spherocytes make them apt to destruction.
- Indirect hyperbilirubinemia is usually present and highly suggestive of hemolytic anemia.
- Watch for signs of organ dysfunction.
- Obtain early hematologic consult.