Drug-Induced Adverse Hematological Interactions/Reactions

First Things First (assess & treat for the following)

  • Does pt have any hematologic abnormalities that require immediate attention?
    • Anemia: Hgb < 10 g/dL in presence of ongoing bleeding, hemolysis, hemodynamic alterations, myocardial ischemia, mental status changes, hypoxemia or decreased oxygen delivery
      • Hgb < 7 g/dL
    • Cyanosis or decreased oxyhemoglobin desaturation consistent w/ methemoglobinemia
    • Neutropenia w/ absolute neutrophil count < 500-1,000/mm3 w/ fever or hypotension
    • Thrombocytopenia < 50,000/mm3 w/ bleeding, < 10,000 mm3
    • Coagulopathy w/ bleeding
    • Intracranial bleeding
    • GI bleeding
    • Pulmonary hemorrhage

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Last updated: April 26, 2010